Phosphatidylcholine

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Phosphatidylcholine

bri·o - the quality of being active, alive, spirited, and vigorous

Phosphatidylcholine Treatment (PC) in Scottsdale, Arizona

Phosphatidylcholine (PC) is a naturally-occurring, necessary component for the formation of cell membranes and the structural and functional integrity of cell membranes throughout the body. PC acts as a supplier of choline, which the liver utilizes as its primary source of fuel (triglycerides). PC is essential in the brain, liver, and intestinal health.

In addition to playing an important role in metabolizing cholesterol, research indicates that PC may be helpful in repairing damage to the liver caused by alcohol, pollutants, and other toxins. In the intestinal tract, PC has a protective effect on the mucosa and acts as an anti-inflammatory.

Although the human body can synthesize choline, levels in membranes decline with age and additional supplementation can be necessary under certain circumstances. When administered via intravenous infusion, it may reverse the deterioration of cell membranes.

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Does Phosphatidylcholine treatment help with energy and fatigue?

As a precursor to the excitatory neurotransmitter acetylcholine, it is reasonable to expect PC to affect energy levels and to reduce fatigue. In various sports activities, PC supplementation has enhanced performance where exercise has depleted choline concentrations (5). Although more research is needed in this area, other populations with depleted choline concentrations who may benefit from PC supplementation include people with chronic fatigue and fatigue secondary to cancer. At GWCIM we found that patients suffering from fatigue from various causes were benefiting from phosphatidylcholine administered intravenously.

Does Phosphatidylcholine treatment help with Mold and Other Toxicities?

We have used PC successfully to treat a number of patients with different toxicity-related syndromes,  most commonly for mold toxicity.  Chronic mold toxicity is very complex and requires a comprehensive treatment approach, in which PC is one of the key elements.

Does Phosphatidylcholine treatment help with brain Injury from strokes or trauma?

There is a growing understanding of the critical role the cell membrane lipids play in brain cell recovery.  PC is one of the key membrane lipids, and its use has been suggested as an effective treatment for strokes and traumatic brain injury. (6)

Safety:

Standard toxicological assessments indicate no significant acute or chronic toxicity from PC, as well as no mutagenicity and no teratogenicity. PC is well tolerated at daily intakes of up to 18 grams. (7) PC is not recommended for people taking acetylcholinesterase (AChE) inhibitor medications since this combination may excessively increase acetylcholine levels and potentially cause cholinergic side effects.

References:

  1. Zeisel SH, Blusztajn JK. Choline and human nutrition. Annu Rev Nutr 1994;14:269-296.
  2. Phosphatidylcholine. Altern Med Rev. 2002 Apr;7(2):150-4.
  3. Jenkins PJ, Portmann BP. Use of polyunsaturated phosphatidylcholine in HBsAg negative chronic active hepatitis: results of a prospective double-blind controlled trial. Liver 1982;2:77-81.
  4. Niederau C, Strohmeyer G, Heintges T, Peter K, Göpfert E. Polyunsaturated phosphatidyl-choline and interferon alpha for treatment of chronic hepatitis B and C: a multi-center, randomized, double-blind, placebo-controlled trial. Hepatogastroenterology. 1998
  5. Jäger R, Purpura M, Kingsley M. Phospholipids and sports performance. J Int Soc Sports Nutr. 2007 Jul 25;4:5.
  6. Ali Mousavi S, Khorvash F, Hoseini T. The efficacy of citroline in the treatment of ischemic stroke and primary hypertensive intracerebral hemorrhage; a review article. ARYA Atheroscler. 2010 Fall;6(3):122-5.
  7. Kidd PM. Phosphatidylcholine, a superior protectant against liver damage. Altern Med Rev 1996;1:258-274.

What Is Phospholipid Therapy?

Every cell in your body is encapsulated by a membrane composed of a double layer of phospholipids and the most abundant phospholipid is Phosphatidylcholine (PC).  Phosphatidylcholine is the pivotal phospholipid that is prevalent in healthy young cell membranes and as we get older and/or ill this phospholipid gets replaced with less beneficial phospholipids and this lipid layer can trap and store many toxins.  These toxins can impact cell membrane and mitochondrial function (cells energy production) as well as cellular communication.  Phosphatidylcholine gets incorporated into the cell membrane and improves its integrity and serves to improve the transport of nutrients and export toxins across the cell membrane.

Phosphatidylcholine is also a good source of choline, which is the main substrate for the production of the memory enhancing neurotransmitter, acetylcholine.  Phosphatidylcholine is also an excellent fat emulsifier and thus is helpful to improve serum lipid profiles.

Typically, a two-hour infusion of 875 mg – 1750 of Phosphatidylcholine is given 1 – 3 per week.  At least 10 treatments of PC are recommended.  It has been our experience that the patient starts to notice significant health benefits between 8 to 10 treatments.  This is why we recommend the initial 10 treatments in a 1 – 2-month timeframe, so the patient and practitioner can evaluate this therapy benefit in a timely fashion.   Sometimes I.V. glutathione is given right after this PC therapy for additional therapeutic benefit.

Why should you do this?

Chronic illness is associated with poor cell membrane health.  This impacts conditions such as vascular (blood flow to heart, brain and extremities) disease, high cholesterol, liver disease, autoimmune disease, mood disorders, migraines and multiple neurodegenerative disorderssuch as Alzheimer’s, Parkinson’s, dementia & memory loss.  By replenishing your cell membranes with healthy phospholipids, you can expect to improve overall cellular function as well as improve transport of important nutrients into the cell and export common toxic compounds such as heavy metals, organic pollutants and chemicals like PCB’s and pesticides from the cell.

Are there any significant side effects?

The only relatively common side effect is lowering of the blood pressure and associated lightheadedness.  This is not a dangerous situation and not a reason to discontinue the treatment.  Another side effect might be loose stools.  Occasionally even in good veins there can be some irritation.  Most patients have no complaints.

Role In Detoxification

We hear about the latest “detox” diet, program or trend in the media practically every day. But what does “detoxification” really mean? Does it work? And if so, how do you properly “detoxify” your body?

Your body converts all types of substances into less toxic “metabolites”—molecules that are byproducts of normal metabolism. These substances are then eliminated via bile and urine. However, when it comes to particularly toxic foreign substances—from Tylenol to alcohol to heavy metals to pesticides and more—special processes are needed.

This is where your liver comes in. It is responsible for “conjugating” or modifying these toxic foreign substances so that they can be safely excreted from your system.

Like any of us, your poor liver can’t do its job as well when it’s overworked. When too many toxins enter your body at one time, the liver stores them for later excretion. But since we are constantly bombarded by toxic substances it never gets around to the job. So the toxins remain in your body, which can lead to long-term health complications.

This is especially likely to happen if you are fatigued, stressed out, suffer from fatty liver, drink large quantities of alcohol, smoke, or suffer from other toxic exposures. Your liver also gets overworked when you are on an active weight loss program since heavy metals and toxic organic compounds accumulate in fat and are released into circulation as the fat is lost.

Making sure that your liver is functioning optimally is crucial. And the good news is that you can give your liver a helping hand in its war on toxins. This IV is a perfect way to do that.

We start with phosphatidylcholine (PC), and abundant natural compound found in all cell membranes and the chief molecule that forms the protective barrier around your cell and mitochondrial membranes.

These membranes (along with fat deposits) may store much of the toxic load in our bodies. They also allow the transport of substances in and out of the cell and mitochondria. So you can see why giving them the support they need is so important.

We also add in a little glutathione (GSH)—the body’s master antioxidant. GSH attaches to toxic substances like heavy metals and xenobiotics to help neutralize them until they are eliminated.

Use this IV to support healthy liver function. It’s an ideal therapy if you are stressed out, fatigued, have “brain fog”, have difficulty concentrating, if you smoke or drink, or if you are on an active weight loss program. In addition to the health benefits of improved liver function, you may also experience increased energy and focus as a result of higher acetylcholine (a neurotransmitter) levels when you undergo this treatment.

References

  1. Phosphatidylcholine. Altern Med Rev. 2002 Apr;7(2):150-4.
  2. Buchman AL, Dubin M, Jenden D, Moukarzel A, Roch MH, Rice K, Gornbein J, Ament ME, Eckhert CD. Lecithin increases plasma free choline and decreases hepatic steatosis in long-term total parenteral nutrition patients. Gastroenterology. 1992 Apr;102(4 Pt 1):1363-70.
  3. Mitzscherling K, Volynets V, Parlesak A. Phosphatidylcholine reverses ethanol-induced increase in transepithelial endotoxin permeability and abolishes transepithelial leukocyte activation. Alcohol Clin Exp Res. 2009 Mar;33(3):557-62
  4. Navder KP, Baraona E, Lieber CS. Polyenylphosphatidylcholine decreases alcoholic hyperlipemia without affecting the alcohol-induced rise of HDL-cholesterol. Life Sci. 1997;61(19):1907-14
  5. Jenkins PJ, Portmann BP. Use of polyunsaturated phosphatidyl choline in HBsAg negative chronic active hepatitis: results of prospective double-blind controlled trial. Liver 1982;2:77-81
  6. Visco G. Polyunsaturated phosphatidylcholine (EPL) associated with vitamin B-complex in the treatment of acute viral hepatitis-B. La Clinica Terapeutica 1985;114:183-188
  7. Ilic V, Begic-Janev A. Therapy for HBsAg positive chronically active hepatitis. Med Welt 1991;42:523-525
  8. Niederau C, Strohmeyer G, Heintges T, Peter K, Gapfert E. Polyunsaturated phosphatidyl-choline and interferon alpha for treatment of chronic hepatitis B and C: a multi-center, randomized, double-blind, placebo-controlled trial. Hepatogastroenterology. 1998 May-Jun;45(21):797-804.
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