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How Does Ozone Therapy Work? Know the Facts

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This guide answers the following question – How does ozone therapy work?

Ozone is best known as the UV-protection layer in the earth’s upper atmosphere. However, ozone has many other uses on the ground, particularly in industrial chemical processes and sterilization. But ozone therapy is perhaps the most exciting ozone application yet.

Ozone is not new to the medical world. Reports of ozone being used to disinfect and treat diseases go as far back as the mid-1800s. Ozone therapy techniques have massively improved, making for more effective and versatile treatments.

Here is an overview of ozone therapy, detailing how it works as an alternative treatment for various ailments and health conditions.

How Does Ozone Therapy Work?

Ozone is a gas made up of 3-atom oxygen molecules, O3. It’s one of the three gaseous allotropes of oxygen. The other two are dioxygen O2 (in breathable air) and tetraoxygen O4. It has a characteristic pale blue tinge only visible in high concentrations and an odor generally described as sweet and pungent.

The gas partially dissolves in water; it’s 13 times more soluble than regular oxygen. It’s also a powerful oxidizer, especially in its aqueous form, since it readily dissociates into highly reactive oxygen species. In the air, ozone has a half-life of about 12 hours and between 20-30 minutes in solution. These are the unique chemical behaviors that give ozone its therapeutic properties.

The Science Behind Ozone Therapy

Once in the body, ozone dissolves in plasma and tissue fluids and breaks down to form reactive oxygen species (ROS), such as hydroxyl radicals, peroxides, and singlet oxygen. Then, a series of organic reactions occur between the ROS and free radicals (products of cellular metabolism), raising oxygen concentration and triggering antioxidation in the surrounding tissue. One study showed that ozone therapy could balance these reactions to stimulate an adaptive antioxidant response in healthy tissues and cells.

Besides relieving oxidative stress, here are four more therapeutic functions linked to ozone treatment:

1. Killing Infectious Pathogens

Ozone started as a water purification solution before making its way to medicine. It’s still used to sterilize swimming pools, water reservoirs, and drinking water. Ozone is an antimicrobial agent far more effective at killing and deactivating bacteria, fungi, yeast, and viruses than chlorine. Some researchers have even proposed ozone therapy as an alternative treatment for SARS-CoV-2 due to its high antimicrobial potency.

2. Boosting Immunity

Ozone therapy is closely linked to immune vitality and performance. Research shows that ozone therapy boosts immunity through several physiological mechanisms. One of the best-known mechanisms involves increasing cytokine production. Cytokines are small proteins essential for controlling the functions and growth of immune cells. They modulate inflammation by stimulating, proliferating, and activating immune response agents.

3. Rejuvenating Cells

Tissues and cells get a massive boost of oxygen from ozone infusion. Mitochondria, the cell’s powerhouse, use this influx of oxygen to generate energy in the form of adenosine triphosphate (ATP). In turn, this new energy supercharges metabolism and detoxification at the cellular scale. This action raises energy levels and stimulates the cells to grow, heal, and repair themselves naturally.

4. Relieving Pain and Stress

The effects of antioxidation, anti-inflammation, and cell revitalization combine to relieve pain in aching muscles, joints, and tissues. Physical health plays a significant role in mental and emotional well-being, too. As the body relaxes, energizes, and heals, so does the mind.

Several publications show well-documented evidence of ozone’s effectiveness in treating various pathogenic and inflammatory diseases. However, the FDA does not approve the use of ozone as a form of medical treatment. Admittedly, O3 therapy lacks satisfactory scientific backing due to limited clinical research. But still, it’s fully recognized as a medical treatment in many parts of the world, specifically most of Asia and Europe.

How Is Ozone Administered?

Somewhat ironically, inhaling ozone can be harmful to the respiratory system. Ozone inhaled in small doses can cause chest pain, throat irritation, coughing, and shortness of breath. It may also exacerbate respiratory diseases such as Chronic Obstructive Pulmonary Disease (COPD), bronchitis, and asthma. Elevated or repeated exposure to ozone can lead to irreversible lung damage. However, ozone tolerance and effects vary from person to person.

The U.S. Environmental Protection Agency (EPA) considers ozone an air pollutant. According to the EPA, the standard ozone exposure is 0.07 ppm averaged over 8 hours.

Medical ozone is never administered into the body through the respiratory tract. Instead, ozone therapists commonly use the following methods to infuse ozone into the bloodstream, lymphatic system, and other tissues:

Intravenous (IV) Infusion

In this treatment, 50-100 ml of blood is drawn from the patient, mixed with ozonated saline, and returned to the patient using a dropper. This is also known as “Autohemotherapy,” the most effective and versatile ozone treatment.

Rectal Insufflation

This method involves “blowing” ozone gas into the rectum. The ozone is kept in a bag and directed about 3 inches into the rectum through a unique tube. Most of the ozone gets absorbed by the colon’s walls, while some amount lingers in the gut to kill off harmful pathogens and parasites. Rectal insufflation is more straightforward, quicker, and less invasive than ozone IV. Patients can even do it themselves at home. It’s also ideal for promoting gut health.

Ozone Saunas

Ozone saunas such as the HOCATT Ozone Sauna administer ozone gas through the skin. The entire body (apart from the head) is enclosed in a special air-tight pod in which a mixture of ozone and hot steam is continually pumped. The hot steam causes pores on the skin to open, through which the ozone percolates into the bloodstream, the lymphatic system, and fat tissues. This treatment is ideal for detoxifying, relieving stress and pain, accelerating wound healing, and rejuvenating the skin. It also elevates energy levels and helps with weight loss.

Ozonated Water and Oils

Taking water or oils enriched with medical ozone has more or less the same effect as rectal insufflation. However, some oils are meant for external application on the skin. According to a 2020 study, ozonated rubbing oils help check harmful microbes on the skin’s surface, disinfect and close wounds, and restore damaged skin tissue.

Intra-Articular Injection

This procedure injects an ozone solution intravenously into the patient’s aching joints. Intra-articular injections are commonly used to relieve pain and discomfort in arthritis patients, particularly those with knee osteoarthritis. This treatment is also used on patients recovering from joint injuries and surgeries.

Is Ozone Therapy the Way to Go?

Ozone therapy is not just another New Age medicine fad. It is anchored on scientific foundations and administered by highly trained medical practitioners. On top of that, ozone is a proven alternative and supplemental treatment for numerous health conditions, including arthritis, immune deficiency, viral diseases, muscular degeneration, and cancer. Additionally, it’s known to promote wellness and youthfulness.

For those struggling with chronic aches, fatigue, stress, or medicated ailments, an ozone infusion might be the reinvigoration and relief they’ve been looking for. They should talk to a doctor to determine if ozone therapy is right for them.

Meet the Author
Brio-Medical, Scottsdale AZ, is a natural, holistic, and integrative expert in the cancer field. He is the medical director at Brio Medical, a holistic, integrative cancer healing center in Scottsdale, Arizona. Brio-Medical received his Bachelor of Arts from Louisiana Tech University and his Doctor of Medicine from LSU Health Sciences Center. He is Board Certified in Obstetrics and Gynecology and served as the Chief Resident in Obstetrics and Gynecology at the University of Tennessee. Brio-Medical is a Fellow in Functional and Regenerative Medicine, is a medical Advisor for NEO7 Bioscience and has been named as the President of the North American Society of Laser Therapy Applications (NASLTA).

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