Welcome to the CNS Lymphoma Center at Dana-Farber Brigham Cancer Center, where we provide expert and comprehensive care for patients with central nervous system (CNS) lymphoma. As a dedicated team of specialists, we are committed to offering advanced treatment options and conducting leading-edge research in the field. With our multidisciplinary approach and focus on integrative oncology, we strive to provide the best possible care for patients with CNS lymphoma.
Our center offers a range of treatment options, including surgery, chemotherapy, radiation therapy, immunotherapy, targeted therapies, and access to clinical trials. We understand that each patient is unique, and we work closely with our patients to develop individualized treatment plans that address their specific needs and goals. Our team consists of experts in neuro-oncology, hematologic oncology, radiation oncology, neurosurgery, and ophthalmology, ensuring that every aspect of the patient’s care is addressed.
At the CNS Lymphoma Center, we also prioritize comprehensive support services for both patients and their families. Our psychosocial oncology, cancer neurology, and pain management programs are designed to help patients manage their symptoms and improve their quality of life. We also offer additional support services, such as social workers, nutritionists, and support groups, to ensure that our patients have access to the comprehensive care they need.
- We provide expert and comprehensive care for patients with central nervous system (CNS) lymphoma.
- Our treatment options include surgery, chemotherapy, radiation therapy, immunotherapy, targeted therapies, and access to clinical trials.
- We take a multidisciplinary approach, collaborating with specialists in various fields to develop individualized treatment plans.
- We offer comprehensive support services to help patients manage their symptoms and improve their quality of life.
- Our focus on integrative oncology ensures that we provide the best possible care for patients with CNS lymphoma.
What is CNS Lymphoma?
CNS lymphoma, also known as central nervous system lymphoma, is a rare form of non-Hodgkin lymphoma that specifically affects the brain and spinal cord. It can occur either as a primary lymphoma, originating in the CNS, or as a secondary lymphoma, spreading to the CNS from other sites in the body.
Diagnosing CNS lymphoma involves procedures such as brain biopsy or surgery to obtain tissue samples for examination. Once diagnosed, various treatment options are available to manage the disease and improve patient outcomes. These options may include chemotherapy, radiation therapy, surgery, and participation in clinical trials.
Multidisciplinary Approach to Treatment
The CNS Lymphoma Center at Dana-Farber Brigham Cancer Center takes a multidisciplinary approach to treatment. We understand that central nervous system lymphoma requires specialized expertise from various fields to ensure the best possible outcomes for our patients. That’s why our team consists of experts from diverse specialties, including neurological oncology, hematologic oncology, radiation oncology, neurosurgery, and ophthalmology.
Collaboration is at the heart of our approach. Our team of dedicated healthcare professionals works closely together to develop individualized treatment plans for each patient. We believe that by combining our knowledge and expertise, we can provide comprehensive and personalized care that addresses the unique needs of every individual.
Our team includes highly skilled neuro-oncologists who specialize in the diagnosis, management, and treatment of brain and spinal cord tumors. Our neurological oncology experts have extensive experience in understanding the complex nature of CNS lymphoma and are at the forefront of the latest advancements in the field.
In addition to neurological oncology, our team also includes hematologic oncologists who specialize in blood cancers, radiation oncologists who deliver targeted radiation treatments, neurosurgeons who perform delicate surgeries when necessary, and ophthalmologists who provide specialized eye care for patients with CNS lymphoma.
Individualized Treatment Plans
Each patient’s journey begins with a comprehensive evaluation and diagnosis by our team of experts. We take the time to understand each patient’s unique medical history, personal circumstances, and treatment goals. Based on this information, we develop a tailored treatment plan that considers the most appropriate therapies for their specific needs.
Our multidisciplinary approach allows us to draw on the collective wisdom and experience of our team members. We regularly collaborate and discuss cases to ensure that our treatment plans reflect the latest advances in the field and encompass a wide range of therapeutic options.
Continuum of Care
Our commitment to our patients goes beyond the initial treatment phase. We provide continuous support and comprehensive care throughout the entire treatment journey. Our team of experts actively monitors each patient’s progress, making adjustments to the treatment plan as necessary.
We also prioritize providing access to cutting-edge clinical trials and innovative treatment options. As leaders in the field, we are dedicated to advancing the knowledge and understanding of CNS lymphoma through ongoing research and clinical trials.
With our multidisciplinary approach, we aim to provide the highest quality care, tailored to the unique needs of each patient. At the CNS Lymphoma Center, you can trust that you are receiving the expertise and personalized attention that you deserve.
Treatment Options for CNS Lymphoma
When it comes to treating CNS lymphoma, there are several options available to patients. These treatment modalities can help manage the disease and improve patient outcomes. The treatment options for CNS lymphoma include systemic therapies, surgery, radiation therapy, and participation in clinical trials.
Systemic therapies such as chemotherapy, immunotherapy, and targeted therapy are commonly used in the treatment of CNS lymphoma. These therapies work by targeting cancer cells throughout the body, including those in the central nervous system. They can help shrink tumors, reduce symptoms, and improve overall survival rates. Some commonly used systemic therapies for CNS lymphoma include:
- Chemotherapy: This involves the use of drugs that kill or slow down the growth of cancer cells. Different chemotherapy regimens may be used depending on the specific type and stage of CNS lymphoma.
- Immunotherapy: This treatment harnesses the power of the immune system to fight cancer. It can help boost the body’s natural defenses and target cancer cells.
- Targeted Therapy: This type of therapy specifically targets cancer cells by blocking the specific molecules or pathways that are essential for their growth and survival.
Surgery plays a limited role in the treatment of CNS lymphoma. It is typically reserved for cases where a large mass is causing acute symptoms or neurological deficits. The goal of surgery in these cases is to remove the tumor and relieve pressure on the surrounding structures. However, due to the delicate nature of the brain and spinal cord, surgery is not always possible or recommended for CNS lymphoma.
Radiation therapy is often used in the treatment of CNS lymphoma to target cancer cells directly and prevent recurrence. Different techniques may be used depending on the location and size of the tumor. Some common radiation therapy techniques for CNS lymphoma include:
- 3-Dimensional Conformal Radiation Therapy: This technique uses specialized imaging technology to map out the tumor and deliver precise doses of radiation to the affected area while sparing nearby healthy tissue.
- Stereotactic Radiosurgery: This is a non-invasive radiation therapy technique that uses highly focused radiation beams to target small tumors or lesions in the brain.
Clinical trials offer patients with CNS lymphoma the opportunity to explore new treatment options and contribute to the advancement of medical knowledge. These trials may involve innovative therapies or combinations of treatments that are not yet widely available. Participating in a clinical trial gives patients access to cutting-edge treatments and personalized care. It is important for patients to discuss the potential benefits and risks of participating in a clinical trial with their healthcare team.
Next, let’s explore the various support services available for patients and their families who are navigating the challenges of CNS lymphoma.
|Chemotherapy, immunotherapy, targeted therapy
|Removal of large masses causing acute symptoms
|Precise targeting of cancer cells in the central nervous system
|Exploring new treatment options and advancements
Support Services for Patients and Families
At the CNS Lymphoma Center, we are committed to providing comprehensive care not only to our patients but also to their families. We understand that dealing with central nervous system lymphoma can be challenging, both physically and emotionally. That’s why we offer a range of support services to ensure that patients and their families receive the holistic care they need.
Psychosocial oncology is an essential part of our comprehensive care approach. Our team includes dedicated professionals who specialize in providing psychological and emotional support to patients and their families. Through counseling, therapy sessions, and support groups, we help our patients navigate the emotional impact of their diagnosis and treatment, promoting overall well-being and resilience.
Our cancer neurology services focus on managing neurological symptoms and complications related to CNS lymphoma. We have a team of neurologists experienced in diagnosing and treating the specific neurological issues that may arise during the course of the disease. By closely monitoring patients’ neurological function and providing targeted interventions, we strive to enhance quality of life and minimize treatment-related side effects.
Pain can be a significant concern for patients with CNS lymphoma. Our pain management specialists work closely with patients to develop personalized strategies for pain control and symptom management. By utilizing various techniques, including medication management, interventional procedures, and integrative therapies, we strive to improve comfort and enhance patients’ overall well-being.
Additional Support Services
In addition to psychosocial oncology, cancer neurology, and pain management, we offer a range of additional support services to address the diverse needs of our patients and their families. Our team includes social workers who provide assistance with practical matters such as insurance, transportation, and financial resources. Nutritionists are also available to provide dietary guidance and support for maintaining optimal health during treatment. We also facilitate support groups where patients and their loved ones can connect with others facing similar challenges, fostering a sense of community and understanding.
At the CNS Lymphoma Center, we are dedicated to providing comprehensive care that goes beyond medical treatment. Through our support services, we aim to support the well-being of our patients and their families, offering them the resources they need to navigate their CNS lymphoma journey with confidence and resilience.
Diagnosis of CNS Lymphoma
The diagnosis of CNS lymphoma involves multiple steps to accurately identify and understand the nature of the disease. Our team of experts utilizes advanced diagnostic techniques to ensure an accurate diagnosis and develop an appropriate treatment plan for each patient.
Brain Biopsy or Surgery
A brain biopsy or surgery is often performed to obtain a tissue sample for further examination. This procedure is conducted by a skilled neurosurgeon to collect a sample of the tumor. The obtained tissue is then sent to a neuropathologist for analysis, where they evaluate the cellular characteristics and determine the specific type of lymphoma involved.
In addition to a brain biopsy or surgery, diagnostic work-up may include various imaging tests to evaluate the extent of the disease and guide treatment decisions. These imaging tests provide detailed information about the brain and other parts of the body affected by CNS lymphoma.
One of the commonly used imaging tests is magnetic resonance imaging (MRI) of the brain and spinal cord. This non-invasive procedure uses powerful magnets and radio waves to create detailed images, allowing physicians to visualize the location, size, and characteristics of the tumors.
The evaluation of the eyes is also an essential part of the diagnostic process. Ophthalmologists examine the eyes to detect any lymphoma involvement, as CNS lymphoma can sometimes manifest with ocular symptoms.
A PET/CT scan of the body may also be conducted to assess if the lymphoma has spread beyond the central nervous system. This imaging technique combines positron emission tomography (PET) and computed tomography (CT) to produce images that reveal areas of abnormal metabolic activity, indicating the presence of cancer cells in other organs or tissues.
By combining the results of the brain biopsy or surgery, imaging tests, and other diagnostic procedures, our multidisciplinary team thoroughly evaluates each case of CNS lymphoma. This comprehensive evaluation ensures a precise diagnosis, enabling us to create a tailored treatment plan that suits the individual needs of every patient.
|Brain biopsy or surgery
|Obtain tissue sample for further analysis
|Imaging tests (MRI, PET/CT scan)
|Evaluate the extent and location of the disease
|Assess lymphoma involvement in the eyes
Systemic Therapy for CNS Lymphoma
Systemic therapy plays a crucial role in the treatment of central nervous system (CNS) lymphoma. It involves the use of medications that can reach cancer cells throughout the body, targeting both the brain and other affected areas. One commonly used systemic therapy for CNS lymphoma is high-dose methotrexate.
High-dose methotrexate is a potent chemotherapy drug that has shown significant effectiveness in treating CNS lymphoma. It is often used as a single-agent therapy or in combination with other chemotherapy drugs to achieve optimal outcomes.
While high-dose methotrexate is a well-established treatment option, ongoing clinical trials are exploring new combinations of chemotherapy, stem cell transplant, and immunotherapy. These trials aim to enhance treatment efficacy, reduce side effects, and further improve patient outcomes.
Advantages of Systemic Therapy for CNS Lymphoma
Systemic therapy offers several advantages in the treatment of CNS lymphoma:
- It can target cancer cells not only in the brain but also in other parts of the body, providing a comprehensive approach to treatment.
- High-dose methotrexate has demonstrated efficacy in reducing tumor size and improving overall survival rates.
- Systemic therapy can be combined with other treatment modalities, such as radiation therapy or surgery, for a multimodal approach.
Overall, systemic therapy is a valuable treatment option for CNS lymphoma patients, and ongoing clinical trials hold promise for the development of new and improved strategies.
Surgery for CNS Lymphoma
Surgery plays a limited role in the primary treatment of CNS lymphoma. However, in cases where a large mass is causing acute symptoms, surgical intervention may be necessary. Advanced surgical techniques, such as functional MRI and intra-operative MRI, are employed to achieve maximum tumor resection while minimizing damage to surrounding brain tissue. In certain situations, awake surgery, a specialized approach, may be utilized to mitigate the risk of brain damage.
While the focus of CNS lymphoma treatment primarily revolves around systemic therapies and radiation therapy, surgical procedures can be essential in select cases to alleviate symptoms or reduce tumor burden. Surgeons, working closely with neuro-oncologists and other specialists, employ their expertise to navigate the complex landscape of CNS lymphoma surgery.
Advanced Surgical Techniques
Advanced surgical techniques are employed during CNS lymphoma surgery to optimize outcomes and minimize complications. Functional MRI (fMRI) is used to map critical areas of the brain responsible for crucial functions such as movement, speech, and cognition. This pre-operative planning allows surgeons to navigate around these areas, reducing the risk of functional deficits.
Intra-operative MRI (iMRI) is another innovative technology that enables surgeons to perform real-time imaging during the procedure. This allows for precise tumor localization and evaluation of resection adequacy, ensuring that as much tumor tissue as possible is removed while preserving healthy brain tissue.
Awake surgery, also known as awake craniotomy, is sometimes employed to minimize the risk of neurological damage during tumor resection. In this procedure, the patient is awake and alert, enabling real-time monitoring of brain function throughout the surgery. Awake surgery allows neurosurgeons to remove tumors located in critical brain areas while avoiding damage to vital neural structures.
Benefits and Considerations
While surgery for CNS lymphoma is not a primary treatment modality, it offers several benefits in specific cases:
- Relief of acute symptoms caused by large tumor masses
- Debulking or decreasing the size of tumors to improve the efficacy of subsequent therapies
- Accurate tissue diagnosis through biopsy
It is important to note that surgery for CNS lymphoma carries certain considerations:
- Risk of infection and other surgical complications
- Potential for neurologic deficits, depending on the location of the tumor
- The need for close collaboration between surgical and oncologic teams to formulate comprehensive treatment plans
Given the specialized nature of CNS lymphoma surgery, it is crucial for patients to receive care from experienced neurosurgeons and a multidisciplinary team of healthcare professionals.
Radiation Therapy for CNS Lymphoma
Radiation therapy is a crucial treatment option for patients with central nervous system (CNS) lymphoma, depending on the type and location of the tumor. It involves the use of high-energy X-rays or other forms of radiation to target and destroy cancer cells in the brain or spinal cord. Radiation therapy is typically considered after surgery or chemotherapy to further eradicate cancer cells and reduce the risk of recurrence.
To ensure the optimal delivery of radiation, advanced techniques such as 3-dimensional conformal radiation therapy (3D-CRT) and intensity-modulated radiation therapy (IMRT) are utilized. These methods allow for precise targeting of specific areas within the brain, minimizing damage to surrounding healthy tissue. With 3D-CRT, multiple radiation beams are shaped to match the contours of the tumor, resulting in effective treatment with minimal side effects. IMRT further enhances the precision by modulating the intensity of each beam, enabling more conformal radiation delivery.
In cases where the tumors are difficult to access or deeply seated within the brain, stereotactic radiosurgery (SRS) may be employed. This non-invasive technique uses multiple highly focused radiation beams to precisely target the tumor, achieving a high dose of radiation while sparing healthy tissues nearby. SRS is commonly used for patients with small CNS lymphoma tumors or those who are unable to undergo surgery.
Radiation Therapy for CNS Lymphoma: Benefits and Considerations
Radiation therapy offers several benefits for patients with CNS lymphoma:
- Effective tumor control: Radiation therapy directly targets cancer cells and can provide long-term tumor control.
- Precise treatment delivery: Advanced techniques like 3D-CRT, IMRT, and SRS enable accurate targeting and minimize radiation exposure to healthy tissues.
- Minimal invasiveness: Radiation therapy is a non-invasive treatment option, reducing the need for surgery.
- Adjunct to other treatments: Radiation therapy is often used in combination with surgery and chemotherapy to maximize treatment efficacy.
However, radiation therapy also has certain considerations and potential risks:
- Side effects: Common side effects include fatigue, hair loss, skin changes, and temporary cognitive changes. However, these side effects are typically temporary and resolve after treatment.
- Risk of secondary malignancies: Although rare, radiation therapy may increase the risk of developing other types of cancer in the future.
- Effect on neurocognitive function: High-dose radiation therapy has the potential to impact neurocognitive function, and patients may experience memory loss or difficulty concentrating.
It is important for patients and their healthcare team to weigh the potential benefits and risks of radiation therapy and discuss individualized treatment plans based on the specific characteristics of the CNS lymphoma.
|Advantages of Radiation Therapy for CNS Lymphoma
|Considerations and Potential Risks
Clinical Trials for CNS Lymphoma
At Dana-Farber Brigham Cancer Center, we are committed to advancing the treatment options for CNS lymphoma through clinical trials. Our clinical trials explore innovative treatments, including new systemic therapies, surgical techniques, and radiation treatments. Participating in a clinical trial provides patients with the opportunity to access cutting-edge treatments and contribute to the advancement of knowledge in the field of CNS lymphoma.
Advantages of Clinical Trials
Participating in a clinical trial offers several potential benefits:
- Access to novel treatment options that may not be available outside of the clinical trial setting
- Potential for improved treatment outcomes and long-term survival
- Opportunity to contribute to scientific research and advancements in the field of CNS lymphoma
- Close monitoring and specialized care from our experienced medical team
We understand that participating in a clinical trial can be a significant decision. Our dedicated team of medical professionals will guide you through the process, answering any questions and addressing any concerns you may have.
Current Clinical Trials for CNS Lymphoma
Below is a snapshot of some of the ongoing clinical trials for CNS lymphoma:
|An investigation of a new targeted therapy combined with chemotherapy for primary CNS lymphoma
|Assessing the efficacy of a novel immunotherapy agent in treating recurrent CNS lymphoma
|Exploring the use of advanced radiation techniques for improving local tumor control
These are just a few examples of the many clinical trials available at our center. Our team will evaluate your individual case and recommend the most suitable clinical trial for you based on your specific needs and medical history.
By participating in a clinical trial, you not only have the chance to receive innovative treatments but also contribute to the development of new therapies for CNS lymphoma. Talk to our team today to explore the clinical trial options available to you.
Induction and Consolidation Treatment for CNS Lymphoma
The treatment approach for CNS lymphoma involves two important phases: induction treatment and consolidation treatment. These stages are designed to effectively target and manage the disease, aiming for the best possible outcomes.
In the first phase, known as induction treatment, the goal is to shrink the tumors and achieve remission. Chemotherapy plays a central role in this stage, typically administered in cycles. Depending on the specific case, induction treatment may also incorporate the use of rituximab, an antibody drug.
Rituximab is often combined with chemotherapy to enhance its effectiveness by targeting specific proteins on the surface of cancer cells. By doing so, the drug helps the immune system recognize and attack lymphoma cells more efficiently, leading to better treatment responses.
This combination therapy has shown promising results in the treatment of CNS lymphoma, enabling higher response rates and increased overall survival rates for patients.
The second phase of treatment is consolidation treatment, which aims to prevent cancer recurrence and provide long-term disease control. Consolidation treatment may include additional chemotherapy cycles, high-dose chemotherapy with stem cell transplant, or low-dose radiation therapy.
Additional chemotherapy cycles help maintain the remission achieved during induction treatment, ensuring that any remaining cancer cells are effectively eliminated. High-dose chemotherapy with stem cell transplant is an option for selected patients with aggressive disease or who have a high risk of relapse. It involves the administration of high doses of chemotherapy to destroy the cancer cells, followed by the infusion of stem cells to aid in the recovery of the bone marrow.
Low-dose radiation therapy may also be used to target specific areas at risk of recurrence, helping to further reduce the likelihood of cancer returning.
By combining induction and consolidation treatments, healthcare professionals can provide comprehensive and individualized care for patients with CNS lymphoma, increasing the chances of successful outcomes and long-term disease control.
|Additional chemotherapy cycles
|High-dose chemotherapy with stem cell transplant
|Low-dose radiation therapy
Peripheral Neuropathy and Leptomeningeal Involvement
CNS lymphoma, a rare form of non-Hodgkin lymphoma that affects the brain and spinal cord, can lead to various complications, including peripheral neuropathy and leptomeningeal involvement. Peripheral neuropathy refers to numbness or pain in the arms and legs caused by damage to the peripheral nerves. Leptomeningeal involvement, on the other hand, occurs when cancer cells spread to the spaces surrounding the brain and spinal cord, known as the leptomeninges.
To alleviate the symptoms of peripheral neuropathy and leptomeningeal involvement in CNS lymphoma, radiation therapy may be recommended. Radiation therapy involves the use of high-energy X-rays to target and destroy cancer cells. By delivering targeted radiation to the affected areas, radiation therapy can reduce pain, numbness, and other neuropathic symptoms in the arms and legs.
Additionally, for CNS lymphoma tumors located in the brain or leptomeninges, chemotherapy may be administered through direct injection into the spine. This approach allows for precise delivery of medication to the affected areas and can help manage cancer growth and alleviate symptoms of leptomeningeal involvement.
It’s important to note that the specific treatment approach for peripheral neuropathy and leptomeningeal involvement may vary based on the individual patient’s condition and other factors. The healthcare team will evaluate the patient’s overall health and consider the best treatment options, which may include a combination of radiation therapy, chemotherapy, and other interventions.
Summary of Treatment Options for Peripheral Neuropathy and Leptomeningeal Involvement
|High-energy X-rays targeted at the affected areas to reduce pain and numbness
|Chemotherapy (Direct Injection)
|Medication administered through direct injection into the spine for tumors in the brain or leptomeninges
It’s essential for patients with peripheral neuropathy and leptomeningeal involvement to discuss their symptoms and treatment options with their healthcare providers. A comprehensive evaluation and personalized treatment plan can help manage these complications effectively and improve the overall quality of life for patients with CNS lymphoma.
Treatment for Recurrent CNS Lymphoma
After initial treatment, CNS lymphoma may recur in some patients. When this happens, we have additional treatment options available to help fight the cancer. The specific approach depends on several factors, including the patient’s age, location of the cancer, and the number of recurrences.
One of the treatment options for recurrent CNS lymphoma is targeted therapy. Targeted therapy uses drugs or other substances to identify and attack cancer cells specifically. It can help stop the growth and spread of the cancer while minimizing damage to normal cells. This type of therapy is designed to work on specific types of cancers, including CNS lymphoma.
Another treatment option for recurrent CNS lymphoma is radiation therapy, which uses high-energy X-rays or other forms of radiation to kill cancer cells. It can be used to target and destroy cancer cells in the brain or spinal cord. Radiation therapy can be especially beneficial when the cancer recurs in a specific area and localized treatment is needed.
At MSK, we understand that each patient’s situation is unique, and we tailor the treatment plan accordingly. Our expert team will evaluate all factors to determine the best course of action for recurrent CNS lymphoma, taking into account the patient’s overall health and treatment history.
In addition to targeted therapy and radiation therapy, we also offer clinical trials for recurrent CNS lymphoma. Clinical trials provide access to innovative treatments and allow patients to contribute to the advancement of knowledge in the field.
To illustrate the various treatment options for recurrent CNS lymphoma, here is a table summarizing the approach based on key factors:
|Location of Cancer
|Number of Recurrences
As research in CNS lymphoma continues to progress, the treatment landscape for recurrent cases is constantly evolving. At MSK, our dedicated team remains at the forefront of clinical advancements, ensuring patients receive the best care possible.
Pioneering Research and Advancements
At Dana-Farber Brigham Cancer Center, we are dedicated to pushing the boundaries of research and advancements in CNS lymphoma treatment. Our team of experts is at the forefront of innovative clinical trials, aiming to improve treatment outcomes and provide patients with cutting-edge options.
We understand the significance of developing less neurotoxic treatments for our patients. That’s why our researchers are actively exploring new treatment modalities to minimize the impact on neuro-cognition. By studying the effects of treatment on neuro-cognition, we strive to optimize patient care and quality of life.
|Developing novel therapies and targeted approaches
|Exploring immunotherapies, gene therapies, and precision medicine
|Evaluating cognitive function and impact of treatment on neuro-cognition
|Investigating combination therapies for improved efficacy
|Studying the use of advanced imaging techniques in treatment planning
|Assessing long-term neurological effects and rehabilitation strategies
|Identifying biomarkers for personalized treatment selection
|Examining the role of the immune system in CNS lymphoma
|Implementing cognitive rehabilitation programs for patients
At Dana-Farber Brigham Cancer Center, our dedication to research and advancements drives us to discover new possibilities and innovative solutions for the treatment of CNS lymphoma. Through our collaborative efforts and commitment to excellence, we aim to provide our patients with the latest breakthroughs in neuro-oncology.
At the CNS Lymphoma Center, our team of dedicated specialists provides expert care for patients with central nervous system lymphoma. With a focus on integrative oncology, we offer a comprehensive range of treatment options tailored to each individual’s needs.
Our center is committed to staying at the forefront of clinical advancements and research in the field of CNS lymphoma. We actively participate in innovative clinical trials to improve treatment outcomes and explore new therapeutic approaches. Through these efforts, we aim to provide our patients with access to the most cutting-edge and effective treatments available.
In addition to our advanced treatment options, we also offer a wide range of support services to ensure that our patients receive comprehensive care. Our team of experts includes not only oncologists but also professionals in neurology, psychosocial support, and pain management. We understand the importance of addressing both the physical and emotional impact of CNS lymphoma, and we work collaboratively to provide holistic care for our patients and their families.
If you or a loved one has been diagnosed with central nervous system lymphoma, we are here to guide you through every step of your journey. Contact our center today to schedule a consultation with our experienced integrative oncologists and learn more about the personalized treatment options available to you.
What is CNS Lymphoma?
CNS lymphoma is a rare form of non-Hodgkin lymphoma that affects the brain and spinal cord. It can be primary (originating in the CNS) or secondary (spreading from other sites). Diagnosis includes a brain biopsy or surgery, and treatment options include chemotherapy, radiation therapy, surgery, and clinical trials.
What is the multidisciplinary approach to treatment?
The multidisciplinary approach to treatment involves experts from various specialties, such as neuro-oncology, hematologic oncology, radiation oncology, neurosurgery, and ophthalmology, collaborating to develop individualized treatment plans for patients with CNS lymphoma.
What are the treatment options for CNS lymphoma?
The treatment options for CNS lymphoma include systemic therapies such as chemotherapy, immunotherapy, and targeted therapy. Surgery may be performed to remove a large mass causing acute symptoms. Radiation therapy is used to eradicate cancer cells or prevent recurrence. Clinical trials are available for patients who want to explore new treatment options.
What support services are available for patients and families?
The CNS Lymphoma Center provides comprehensive care for patients and their families, including support services such as psychosocial oncology, cancer neurology, pain management, social workers, nutritionists, and support groups. These services aim to help patients manage their symptoms and improve their quality of life.
How is CNS lymphoma diagnosed?
The diagnosis of CNS lymphoma typically involves a brain biopsy or surgery performed by a neurosurgeon. Other diagnostic work-ups may include imaging tests such as MRI of the brain and spinal cord, evaluation of the eyes, and PET/CT scan of the body.
What is systemic therapy for CNS lymphoma?
Systemic therapy is an important treatment option for CNS lymphoma, commonly using high-dose methotrexate either alone or in combination with other chemotherapy drugs. Clinical trials are exploring new combinations of chemotherapy, stem cell transplant, and immunotherapy to improve treatment outcomes.
Is surgery a treatment option for CNS lymphoma?
Surgery is not typically used as a primary treatment for CNS lymphoma. However, in cases where a large mass is causing acute symptoms, surgery may be performed. Advanced surgical techniques are used to maximize tumor resection while minimizing damage to surrounding brain tissue.
How is radiation therapy used in CNS lymphoma treatment?
Radiation therapy is a treatment option for CNS lymphoma depending on the type and location of the tumor. Techniques such as 3-dimensional conformal radiation therapy and stereotactic radiosurgery are used to target specific areas of the brain with minimal damage to healthy tissue.
Are there clinical trials available for CNS lymphoma?
Yes, Dana-Farber Brigham Cancer Center offers a variety of clinical trials for patients with CNS lymphoma. These trials explore innovative treatments, including new systemic therapies, surgical techniques, and radiation treatments.
What is the treatment approach for CNS lymphoma?
The treatment approach for CNS lymphoma involves two phases: induction treatment and consolidation treatment. Induction treatment aims to shrink the tumors using chemotherapy, often combined with rituximab, an antibody drug. Consolidation treatment is used to prevent cancer recurrence and can include additional chemotherapy, high-dose chemotherapy with stem cell transplant, or low-dose radiation therapy.
What are the symptoms of peripheral neuropathy and leptomeningeal involvement?
CNS lymphoma can cause peripheral neuropathy, which includes numbness or pain in the arms and legs. It can also involve the leptomeninges, which are the spaces surrounding the brain and spinal cord. Radiation therapy may be used to reduce symptoms in these cases, and chemotherapy may be injected directly into the spine for tumors in the brain or leptomeninges.
What are the treatment options for recurrent CNS lymphoma?
After initial treatment, CNS lymphoma may recur in some patients. If this happens, additional treatments such as chemotherapy, targeted therapy, or radiation therapy may be used. The specific treatment approach depends on factors such as age, location of the cancer, and the number of recurrences. Clinical trials are also available for recurrent CNS lymphoma.
What research advancements are focused on CNS lymphoma treatment?
Dana-Farber Brigham Cancer Center is at the forefront of research and advancements in CNS lymphoma treatment. Their team is actively involved in designing and implementing innovative clinical trials to improve treatment outcomes. They are also focused on developing less neurotoxic treatments and studying the impact of treatment on neuro-cognition.
What care does the CNS Lymphoma Center provide?
At the CNS Lymphoma Center, patients receive expert care from a team of specialists dedicated to central nervous system lymphoma. The center offers a range of treatment options, support services, and access to clinical trials for personalized and comprehensive care. With a focus on integrative oncology, they strive to provide the best possible care for patients with CNS lymphoma.